It Takes a Matured mAb to Treat Ebolavirus Infection

It takes the time that it takes.

It was five days before my first Christmas in Perth, Australia, and our family had begun to arrive the night before. As the rest of household slept, I quickly threw on a skirt and tank top and left to attend the memorial service for one of my study participants, a 57-year old Anglican minister who had died from motor neurone disease (MND). Though I feared I would be late, I could see people mil...

It takes two to tango

The vertebrate inner ear has time and again surprised neurobiologists by adding new wrinkles to known mechanisms of cellular signaling. among those surprises, was the discovery that nicotinic acetylcholine receptors (related to those that excite muscle) inhibit cochlear hair cells when acetylcholine (aCh) is released from efferent neurons. Inhibition occurs because calcium entering through the ...

It Takes T to Tango

Of three recently cloned T-type voltage-gated calcium channels, alpha(1g) is most likely responsible for burst firing in thalamic relay cells. These neurons burst during various thalamocortical oscillations including absence seizures. In this issue of Neuron, Kim et al. inactivated alpha(1g), and resultant mice were deficient in relay cell bursting and resistant to GABA(B) receptor-dependent ab...

It takes a village.

Iknow what you’re thinking—“it takes a village” is a hackneyed phrase, and what is it doing in P&T? Perhaps you missed a critically important report from the Institute of Medicine (IOM) last winter on an approach for preventing and controlling hypertension.1 It certainly appears that it does take a village to manage high blood pressure in the U.S. As our readers probably know, nearly 73 million...

It takes a village to improve care.